At around 6:30 a.m., crews were dispatched to reports of a house fire in the 4400 block of Matthews Loop South.
On arrival, they found a home heavily impacted by fire and immediately upgraded it to two-alarm.
Officials said crews began to attack the flames while searching for victims, finding two people trapped inside.
One of them died at the scene and the other was taken to a hospital.
The fire was brought under control within 20 minutes after crews arrived, authorities said.
Both Salem police and the Salem Fire Department are working together to investigate the cause of the fire.
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