The Indiana Department of Transportation shut down all lanes of I-74 eastbound and westbound, according to an alert sent around 12:45 a.m. Monday.
The crash happened near mile marker 66.8.
According to Indiana State Police, a driver was heading the wrong way on the interstate when their vehicle collided head-on with a semi truck.
The injured driver was taken to an area hospital.
A westbound lane reopened around 1:22 a.m. while the eastbound lanes remained closed. INDOT indicated all lanes of I-74 reopened around 3:30 a.m.
The crash remains under investigation.
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