Here’s the full schedule below:
| Game | Time/Network* | |
| Week 1: Sunday 9/7 | at Seahawks | 1:05 p.m./FOX |
| Week 2: Sunday 9/14 | at Saints | 10 a.m./FOX |
| Week 3: Sunday 9/21 | vs. Cardinals | 1:25 p.m./FOX |
| Week 4: Sunday, 9/28 | vs. Jaguars | 1:05 p.m./FOX |
| Week 5: Thursday, 10/2 | at Rams | 5:15 p.m./Prime Video |
| Week 6: Sunday, 10/12 | at Buccaneers | 10 a.m./CBS |
| Week 7: Sunday 10/19 | vs. Falcons | 5:20 p.m./NBC |
| Week 8: Sunday 10/26 | at Texans | 10 a.m. PT/FOX |
| Week 9: Sunday 11/2 | at Giants | 10 a.m./CBS |
| Week 10: Sunday 11/9 | vs. Rams | 1:25 p.m./FOX |
| Week 11: Sunday 11/16 | at Cardinals | 1:05 p.m./FOX |
| Week 12: Monday, 11/24 | vs. Panthers | 5:15 p.m./ESPN |
| Week 13: Sunday 11/30 | at Browns | 10 a.m./CBS |
| Week 14: | BYE | |
| Week 15: Sunday 12/14 | vs. Titans | 1:25 p.m./FOX |
| Week 16: Monday 12/22 | at Colts | 5:15 p.m./ESPN |
| Week 17: Sunday, 12/28 | vs. Bears | 5:20 p.m./NBC |
| Week 18: Saturday or Sunday (1/3 or 1/4) | vs. Seahawks | TBD |
Based on opponents’ combined 2024 record, the 49ers have the easiest schedule. According to CBS Sports, San Francisco’s 2025 opponents combined to have a league-worst .415 winning percentage last year.
*All times Pacific
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