The blaze broke out just before 4:50 p.m. Friday in the 400 block of Ellis Street. Fire crews said there was heavy smoke at the scene when they arrived.
Nearby residents and commuters are advised to avoid the area of Ellis Street between Leavenworth and Jones streets until further notice.
SFFD said two people and two dogs were rescued from the fire. San Francisco Fire said one of the two people declined medical treatment.
The cause of the blaze is being probed.
KRON4 has a news crew heading to the location and we will have more updates as they become available.
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