The crash happened around 8 a.m. on northbound I-65 near the interchange to westbound 80/94.
The cattle truck was hauling 127 cows at the time, according to Indiana State Police.
All lanes were blocked, and Indiana State Police were urging motorists to avoid the area.
ISP said Friday morning that it was expected to be an “all-day detail” to get the interstate back open.
WGN’s SkyCam9 showed about a dozen cows in a pen behind the truck. A few have exited the truck safely since then, growing the makeshift herd.
There does not seem to be a significant traffic issue in the area as a result.
The status of the driver and other cows was not immediately known.
This is a developing story.
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