The NFL Week 4 schedule starts with the injury-plagued Denver Broncos heading to Jersey to take on the Saquon Barkley-less Giants. It concludes with a pretty lopsided matchup between the Green Bay Packers and a struggling Atlanta Falcons team.

In between, the Minnesota Vikings will take on the Houston Texans in a must-win game for each team while the Steelers head to Nashville to take on another undefeated team in that of the Titans.

Here’s a look at the NFL Week 4 schedule with game-by-game predictions.

Related: NFL power rankings

NFL Week 4 Thursday Night Football

Denver Broncos at New York Jets

Time/station: 8:20 PM EST, NBC

Broncos-Giants point spread: Broncos -2.5

The wide array of injuries for Denver should give New York a fighting chance here. Taking on a skill group headed by Jeff Driskel, Melvin Gordan and Jerry Jeudy is much different than going up against Drew Lock, Phillip Lindsay and Courtland Sutton, the latter two of whom are Pro Bowlers.

Related: Adam Gase calls the Jets out

As for the Jets, they have been downright miserable thus far on the young season. That included a blowout 31-13 Week 2 loss to an injury-plagued 49ers team. New York lacks an ability to be competitive, ruining Sam Darnold’s ability to progress under center in the process.

NFL Week 4 prediction: Broncos 27, Jets 17

NFL Week 4 Sunday games

Indianapolis Colts at Chicago Bears

Time/station: 1:00 PM EST, CBS

Colts-Bears point spread: Pick em

Chicago has surprised the masses with a 2-0 start to the season. That included a brilliant fourth-quarter performance from Mitchell Trubisky back in Week 1 against Detroit. While the fourth-year quarterback did struggle Week 2, his Bears defense lifted the embattled team leader up. If Matt Nagy and Co. can continue to get these pieces working in unison together, Chicago might very well surprise people.

Related: Ranking NFL defenses

On the other hand, Indianapolis followed up a brutal season-opening loss to Jacksonville with an equally resounding win over Minnesota that saw the Matt Eberflus-led Colts defense hold Kirk Cousins to less than 100 net passing yards while picking the quarterback off three times. I can’t envision a scenario where Trubisky does enough to defeat Indy here.

Week 4 NFL prediction: Colts 23, Bears 16

New Orleans Saints at Detroit Lions

Time/station: 1:00 PM EST, FOX

Saints-Lions point spread: Saints -4.0

At some point the Lions are going to have to seriously consider firing head coach Matt Patricia. A defensive-minded coach dating back to his days with New England, Patricia is overseeing a unit that has allowed 34.5 points per game through two weeks. He’s also 9-24-1 in two-plus seasons as the Lions’ coach.

Related: NFL coaches on the hot seat

Despite New Orleans’ struggles on both sides of the ball in a Week 2 loss to the Raiders, there’s absolutley no chance Detroit hangs with this Super Bowl contender. Sean Payton is a better coach. Drew Brees is still a better quarterback than Matthew Stafford. The Saints’ defense is leaps and bounds ahead of whatever we’d call the Lions on that side of the ball.

NFL Week 4 prediction: Saints 35, Lions 17

Arizona Cardinals at Carolina Panthers

Time/station: 1:00 PM EST, FOX

Cardinals-Panthers point spread: Cardinals -3.5

This could get ugly pretty quick. Carolina’s lack of experience will make for a track meet as Arizona’s offense scores early and often here. There’s no reason to believe that a Panthers defense we’ve seen yield an average of 32.5 points per game will be able to stop MVP candidate Kyler Murray and his weapons on offense, DeAndre Hopkins, Larry Fitzgerald and Christian Kirk.

Related: Top 2020 NFL MVP candidates

Meanwhile, Arizona ranks second in the NFL in scoring defense at 17.5 points per game. The likes of Chandler Jones, Patrick Peterson and Budda Baker make for an elite trio. Despite a strong early-season performance from Teddy Bridgewater in his debut campaign with the Panthers, this game is not going to be that close.

NFL Week 4 prediction: Cardinals 34, Panthers 20

Jacksonville Jaguars at Cincinnati Bengals

Time/station: 1:00 PM EST, CBS

Jaguars-Bengals point spread: Bengals -3.0

Jacksonville nearly pulled off a dramatic comeback against the Tennessee Titans back in Week 2, only to lose by the score of 33-30. Second-year quarterback Gardner Minshew (six touchdowns, two interceptions) and underrated running back James Robinson (210 total yards) are pacing a surprisingly good offense.

In a matchup of two good young quarterbacks, rookie No. 1 overall pick Joe Burrow will look to lead Cincinnati to a home win. He has been tremendous through the first two games of his career, throwing for 509 yards with four total touchdowns and just one interception. I am going to go with Burrow and the Bengals as small home favorites here.

NFL Week 4 prediction: Bengals 24, Jaguars 21

Cleveland Browns at Dallas Cowboys

Time/station: 1:00 PM EST, CBS

Browns-Cowboys point spread: Cowboys -4.0

Dallas’ shocking Week 2 comeback win notwithstanding, this team has struggled to an extent through two games. Primarily, it’s been issues on defense. That unit is giving up nearly 30 points per game. The good news for struggling head coach Mike McCarthy and Co.? Dak Prescott is playing out of his mind. He’s amassed 764 total yards with five touchdowns and zero interceptions through two games.

Related: Best QB/WR duos in the NFL

On the other hand, Cleveland is coming off a narrow Week 2 win over Cincinnati. That came after a disastrous performance in its season opener against the Ravens. Baker Mayfield has thrown just three touchdowns compared to two interceptions while completing less than 60% of his passes. I don’t envision Mayfield being able to take advantage of a questionable Dallas defense.

NFL Week 4 prediction: Cowboys 31, Browns 20

Minnesota Vikings at Houston Texans

Time/station: 1:00 PM EST, FOX

Vikings-Texans point spread: Texans -4.0

The Vikings have been so bad through two weeks that there’s been some talk about the team firing longtime head coach Mike Zimmer. Minnesota is 0-2 on the campaign and is allowing an average of 35.5 points per game. Kirk Cousins threw three interceptions while compiling less than 100 net passing yards in Week 2. Star linebacker Anthony Barr is lost for the season. 

As for the Texans, their performance through the early stages of the season has also been disastrous. It’s also one of the reasons why Bill O’Brien finds himself on the hot seat. Primarily, the issues protecting Deshaun Watson has created the biggest problems. That’s also going to be why I pick Minnesota to come out on top.

NFL Week 4 prediction: Vikings 24, Texans 16

Seattle Seahawks at Miami Dolphins

Time/station: 1:00 PM EST, FOX

Seahawks-Dolphins point spread: Seahawks -6.5

To say that Russell Wilson is playing at an MVP clip would be a gross understatement. The Super Bowl quarterback is completing 82.5% of his passes with nine touchdowns and one interception through two games. Unfortunately for the Seahawks, their defense is also giving up nearly four touchdowns per game. 

That likely won’t be much of an issue against a talent-stricken Dolphins offense led by Ryan Fitzpatrick in Week 4. Miami has scored the seventh-fewest points in the NFL and is allowing a shocking 26 points per game. Even with this game in South Beach, expect Seattle to win going away. 

NFL Week 4 prediction: Seahawks 35, Dolphins 17

Los Angeles Chargers at Tampa Bay Buccaneers

Time/station: 1:00 PM EST, CBS

Chargers-Buccaneers point spread: Buccaneers -4.5

As if the 2020 season wasn’t weird enough amid the pandemic, a recent story breaking from Los Angeles indicating that a team doctor was responsible for Tyrod Taylor’s Week 2 absence adds another layer to this. Apparently, the doctor punctured Taylor’s lung while giving him a shot for pain. This led to rookie No. 6 overall pick Justin Herbert getting the start under center. He almost led the Chargers to a surprising win over Kansas City. 

Related: Top 100 NFL players of 2020

As for the Buccaneers, they have put up an uneven performance through two weeks. Tom Brady has thrown just three touchdowns compared to three interceptions. Rob Gronkowski has all of two catches. That has led to Bruce Arians calling out his team on a near never-ending loop. Despite this, the Buccaneers should be able to take advantage of a green quarterback in this one. 

NFL Week 4 prediction: Buccaneers 27, Chargers 20

Pittsburgh Steelers at Tennessee Titans

Time/station: 1:00 PM EST, CBS

Steelers-Titans point spread: Titans -3.0

The Steelers are finally back. It’s not a coincidence that Pittsburgh’s return to relevance has coincided with Ben Roethlisberger being 100% healthy. The future Hall of Fame quarterback has his Steelers averaging 26 points per game and has thrown five touchdowns compared to one interception.

On the other hand, Tennessee is a perfect 2-0 despite some uneven performances. Ryan Tannehill has tallied six touchdowns compared to zero interceptions on the season. Mike Vrabel’s defense is playing great football. In a game that could be decided at the end, I am going with the home team.

NFL Week 4 prediction: Steelers 28, Titans 24

Baltimore Ravens at Washington Football Team

Time/station: 1:00 PM EST, CBS

Ravens-Washington point spread: Ravens -12.0

Washington’s upset Week 1 win over Philadelphia might have given fans in D.C. false hope that the team will be competitive in 2020. Dwayne Haskins (401 yards, two touchdowns in two games) is very much a work in progress. And while Washington’s defense has improved under new head coach Ron Rivera, it’s not going to make up for ineptitude on offense.

The Ravens are in a dramatically different situation. Lamar Jackson (578 total yards, four touchdowns, zero interceptions) continues to play at an MVP level. Baltimore’s defense also ranks No. 1 in the NFL, yielding an average of 11.0 points per game. This will likely be the biggest blowout on the NFL Week 4 slate.

NFL Week 4 prediction: Ravens 38, Washington Football Team 10

New York Giants at Los Angeles Rams

Time/station: 4:05 PM EST, FOX

Giants-Rams point spread: Rams -9.0

The loss of Saquon Barkley to a season-ending torn ACL is not going to do second-year quarterback Daniel Jones any favors. Without any real weapons to speak of, Jones has struggled big time as a sophomore. He’s thrown two touchdowns compared to three interceptions and has been sacked seven times.

Related: Should the Giants trade Saquon Barkley?

For some reason, the Rams’ offense has improved from a season ago. That’s shocking given that Sean McVay and Co. lost both Todd Gurley and Brandin Cooks during the offseason. One of the primary reasons for this is the return to relevance of embattled quarterback Jared Goff. He’s thrown three touchdowns and just one interception. Look for Los Angeles’ hot start to continue in Southern California during NFL Week 4.

NFL Week 4 prediction: Rams 31, Giants 14

New England Patriots at Kansas City Chiefs

Time/station: 4:25 PM EST, CBS

Patriots-Chiefs point spread: Chiefs -8.0

Cam Newton against Patrick Mahomes. Former NFL MVPs duking it out in a huge AFC battle. This should be a whole lot of fun. For his part, Newton has returned to earlier-career form in his first season with New England. The former No. 1 overall pick has tallied 674 total yards and is leading an offense that’s averaging nearly 26 points per game.

As for Mahomes and the Chiefs, he has the team averaging nearly 29 points per game and has accounted for five touchdowns compared to zero interceptions. With that said, Kansas City did need a late-game field goal against the Chargers to come away with a Week 2 win.

NFL Week 4 prediction: Chiefs 31, Patriots 27

Buffalo Bills at Las Vegas Raiders

Time/station: 4:25 PM EST, CBS

Bills-Raiders point spread: Bills -2.5

Last year’s surprising playoff team heading to Vegas to take on a Raiders squad looking to join the Bills in that category. Surprisingly, this is one of the funnest matchups to detail heading into Week 4. Josh Allen’s emergence to elite status has been stunning. He’s accounted for 804 total yards with seven touchdowns and zero interceptions in two games.

Related: Raiders’ Vegas opener draws high ratings

While Derek Carr continues to struggle getting the ball down the field, he’s the most-accurate we’ve seen the Pro Bowl quarterback be in years. It led to an upset Week 2 win over the New Orleans Saints and has the Raiders undefeated through two games.

NFL Week 4 prediction: Bills 28, Raiders 23

NFL Sunday Night Football Week 4

Philadelphia Eagles at San Francisco 49ers

Time/station: 8:20 PM EST, NBC

Eagles-49ers point spread: 49ers -3.5

Disaster. That’s the best way to describe what has happened to these two teams during the early portion of the 2020 season. Philadelphia is 0-2 and has seen a ton of regression from quarterback Carson Wentz. Meanwhile, San Francisco has dealt with serious injuries to the likes of Jimmy Garoppolo, Raheem Mostert, George Kittle, Deebo Samuel, Dee Ford, Nick Bosa and Richard Sherman. No really. That’s a thing.

Related: Doug Pederson on his way out?

Despite this, the defending NFC champs blew out the New York Jets in Week 3. Garoppolo, Mostert and Samuel should be back for this game. It will lead to another hard-fought win for San Francisco.

NFL Week 4 prediction: 49ers 30, Eagles 17

NFL Monday Night Football Week 4

Atlanta Falcons at Green Bay Packers

Time/station: 8:20 PM EST, ESPN

Falcons-Packers point spread: Packers -5.0

Two teams going in vastly different directions. Atlanta ranks dead last in the NFL in scoring defense, yielding a whopping 39 points per game. Green Bay has dropped 40-plus points in each of their first two games.

That’s why a five-point spread makes absolutely no sense heading into Week 4. Atlanta has nowhere near the weapons on defense to slow down Aaron Rodgers, Davante Adams, Aaron Jones and Co. This is going to be good ole Wisconsin whooping.

Week 4 NFL prediction: Packers 35, Falcons 21

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Author: Vincent Frank