Russian CRISPR scientist announces new controversial effort to edit genes that cause deafness
Russian scientist Denis Rebrikov claims that he’s begun a gene-editing process to eventually enable couples who both carry a specific genetic mutation that causes deafness to birth children who can hear. Rebrikov formerly announced his effort to use the CRISPR tool for gene editing to create babies resistant to HIV. From Nature:
In his e-mail to Nature, Rebrikov makes clear that he does not plan to create (a gene-edited) baby yet — and that his previously reported plan to apply this month for permission to implant gene-edited embryos in women has been pushed back.
Instead, he says that he will soon publish the results of his egg experiments, which also involved testing CRISPR’s ability to repair the gene linked to deafness, called GJB2, in bodily cells taken from people with this mutation. People with two mutated copies of GJB2 cannot hear well without interventions, such as hearing aids or cochlear implants. Rebrikov says these results will lay the groundwork for the clinical work.
Rebrikov adds that he has permission from a local review board to do his research, but that this does not allow transfer of gene-edited eggs into the womb and subsequent pregnancy…
Some scientists and ethicists also call into question the benefits of this procedure because hearing loss is not a fatal condition. “The project is recklessly opportunistic, clearly unethical and damages the credibility of a technology that is intended to help, not harm,” says Jennifer Doudna, a pioneer of the CRISPR gene-editing tool and a biologist at the University of California, Berkeley.